Catecholamine and cyclic nucleotide response of sheep to the injection of Clostridium welchii type D epsilon toxin.
J Med Microbiol, 1979/11;12(4):497-501.
Worthington RW, Bertschinger HJ, Mülders MS
PMID: 229224
Impact factor: 3.196
Abstract
Injection of Clostridium welchii (C. perfringens) type D epsilon toxin into sheep caused large increases in catecholamine and cyclic adenosine 3',5'-monophosphate levels and moderate increases in cyclic guanosine 3',5'-monophosphate levels. Haemoconcentration also occurred. It is suggested that a rapidly developing brain oedema is the stimulus for a release of catecholamines which in turn activates adenyl cyclase. The resulting rise in cAMP causes glycogenolysis and hyperglycaemia.
MeSH terms
Animals; Bacterial Toxins; Blood Glucose; Catecholamines; Clostridium; Cyclic AMP; Cyclic GMP; Dopamine; Epinephrine; Norepinephrine; Sheep
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