Inhibition of human monocyte-macrophage and lymphocyte cytotoxicity to herpes simplex-infected cells by glucan.
J Immunol Methods, 1979;29(4):361-8.
Kohl S, Pickering LK, Diluzio NR
PMID: 229165
Impact factor: 2.287
Abstract
The effect of short term in vitro incubation of glucan--a reticuloendothelial system stimulator--on subsequent cytotoxicity of human monocyte-macrophages (MP) and lymphocytes (L) to Herpes simplex virus-infected cells in a 51Cr-release assay was analyzed. Particulate, cell-associated glucan irreversibly inhibited MP antibody-dependent cellular cytotoxicity (ADCC). In contrast, the inhibition of L-ADCC and L-natural killer cytotoxicity could be reversed by dissociation of glucan and cells utilizing serum gradient centrifugation, a process which did not remove the glucan. These experiments reveal further basic differences between MP and L-ADCC using the reagent glucan.
MeSH terms
Cytotoxicity, Immunologic; Depression, Chemical; Glucans; Herpes Simplex; Humans; Lymphocytes; Macrophages; Monocytes; Simplexvirus
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