Collagenolytic activity of crevicular fluid and of adjacent gingival tissue.
J Dent Res, 1979/11;58(11):2132-6.
Golub LM, Kaplan R, Mulvihill JE, Ramamurthy NS
PMID: 229140
Impact factor: 8.924
Abstract
The fluid in and gingival tissue lining periodontal pockets were collected from male patients undergoing periodontal therapy. The collagenolytic activity of the crevicular fluid, and the ability of the gingiva in culture to degrade (a) an exogenous collagen substrate, and (b) endogenous collagen newly synthesized and labeled with H3-hydroxyproline, were related to the severity of gingival inflammation. Although inflammation appeared to have only a slight effect on gingival collagenolytic activity and on the turnover of collagen newly synthesized in culture, a marked effect was observed on the collagenase activity in the crevicular fluid. This study suggests that the collagen destructive activity of the periodontal lesion can be assessed by monitoring crevicular fluid collagenolytic activity.
MeSH terms
Adult; Collagen; Gingiva; Gingival Crevicular Fluid; Gingivitis; Humans; Hydroxyproline; Male; Microbial Collagenase; Middle Aged; Periodontal Diseases
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