Endogenous digitalis-like activity in mammalian brain.
Proc Natl Acad Sci U S A, 1979/9;76(9):4661-3.
PMID: 228305
Impact factor: 12.779
Abstract
A fraction of brain has been prepared that contains a substance mimicking actions of the digitalis glycosides. It both blocks the binding of [3H]ouabain to Na+,K+-ATPase (ATP phosphohydrolase, EC 3.6.1.3) and inhibits the uptake of 86Rb+ into human erythrocytes. Partial isolation was achieved by Sephadex G-10 fractionation and subsequent desalting. This activity is potentially capable of regulating ionic fluxes and concentration gradients across the cell membrane.
MeSH terms
Animals; Binding, Competitive; Biological Transport, Active; Brain; Digitalis Glycosides; Erythrocyte Membrane; Guinea Pigs; Humans; Microsomes; Ouabain; Rubidium; Sodium-Potassium-Exchanging ATPase
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