Opioid activity of delta O-endorphin in the guinea pig ileum.
Hoppe Seylers Z Physiol Chem, 1979/10;360(10):1453-6.
PMID: 227781
Abstract
The oligopeptides beta- and delta O-endorphin were isolated from porcine and bovine pituitary respectively. Their opiate activity was determined in the guinea pig ileum and compared to that of the pentapeptide methionine-enkephalin and morphine. The rank order of opioid activity was found to be: morphine greater than beta-endorphin = Met-enkephalin greater than delta O-Endorphin which lacks the four C-terminal amino acids of beta-endorphin displayed 60% of the activity of beta-endorphin. These results indicate, that C-terminal amino acids contribute little to the affinity of beta-endorphin for opiate receptors in the guinea pig ileum.
MeSH terms
Animals; Binding, Competitive; Cattle; Endorphins; Enkephalins; Guinea Pigs; Ileum; Kinetics; Morphine; Pituitary Gland; Receptors, Opioid; Swine
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