The effect of pyrophosphate analogues on influenza virus RNA polymerase and influenza virus multiplication.
Arch Virol, 1979;61(3):245-50.
Stridh S, Helgstrand E, Lannerö B, Misiorny A, Stening G, Oberg B
PMID: 227345
Impact factor: 2.685
Abstract
Analogues of pyrophosphate have been tested as inhibitors of influenza virus-RNA polymerase activity in cell-free assays. The most active compound, phosphonoformic acid (PFA), reduced the polymerase activity to 50 per cent at a concentration of 20 muM. The inhibition was dependent on the type of divalent cation present in the assay. PFA at a concentration of 400 muM also inhibited the influenza virus plaque formation by 90 per cent.
MeSH terms
DNA-Directed RNA Polymerases; Diphosphates; Magnesium; Manganese; Orthomyxoviridae; Structure-Activity Relationship; Viral Plaque Assay
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