Orientation of herpes simplex virus type 1 immediate early mRNA's.
Nucleic Acids Res, 1979/9/11;7(1):77-91.
Clements JB, McLauchlan J, McGeoch DJ
PMID: 226944
Impact factor: 19.16
Abstract
We have determined the orientation of 4 immediate early (IE) mRNA's on the herpes simplex virus type 1 genome by mapping cDNA's complementary to the 3'-termini of messages. These IE mRNA's are transcribed by a pre-existing cell RNA polymerase, and we propose a model which allows their synthesis from a circular template using a single virus promoter region. The promoter region, which is located in the two repetitive DNA regions which flank the short unique region of the virus genome, may serve to initiate bidirectional transcription of these IE mRNA's.
MeSH terms
Base Sequence; DNA Restriction Enzymes; DNA, Viral; Genes, Viral; Molecular Weight; Nucleic Acid Hybridization; Poly A; RNA, Messenger; Simplexvirus
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