Sources of energy for the brain and physical dependence on ethanol.
Med Hypotheses, 1979/6;5(6):629-34.
PMID: 226847
Impact factor: 4.411
Abstract
This paper describes a proposed biochemical mechanism to account for physical dependence on ethanol. Long-term exposure to a continuous and plentiful supply of ethanol-derived hydrogens in NADH and ethanol-derived acetyl-CoA (AcCoA) may lead to a decreased rate of production of endogenous hydrogens in NADH and endogenous AcCoA in compensation. It is proposed that physical dependence on ethanol occurs when ketolytic- and glycolytic-based NADH and AcCoA synthetic rates fall below the rate of utilization by the brain; the brain then "depends" on alcohol-derived NADH and AcCoA for normal function.
MeSH terms
Acetyl Coenzyme A; Animals; Brain; Energy Metabolism; Ethanol; Glycolysis; Humans; Ketones; Liver; NAD; Substance Withdrawal Syndrome; Substance-Related Disorders
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