Cellular antiproliferative action exerted by auranofin.
J Rheumatol Suppl, 1979;5:91-7.
Simon TM, Kunishima DH, Vibert GJ, Lorber A
PMID: 226702
Abstract
Auranofin (AF) is a new orally absorbed coordinated gold compound currently undergoing Phase I studies for its use in the treatment of rheumatoid arthritis. Our investigations with RAJI lymphoma, HeLa carcinoma, and EBV-transformed cells indicate AF exerts an inhibitory effect on DNA, RNA, and protein synthesis as assessed by 3H-thymidine, 3H-uridine, and 3H-leucine uptake, respectively. A rapid and persistent dose dependent inhibition of 3H-thymidine uptake was observed at gold concentrations of 50-100 microgram/dl while all parameters were inhibited after a 24 hr exposure to 100 microgram/dl. Reductions in viability and surface morphological changes were also observed. These results suggest AF exerts a significant inhibitory effect on essential biological processes and functions.
MeSH terms
Aurothioglucose; Cell Division; Cell Line; Cell Membrane; Cell Transformation, Viral; DNA; Gold; Herpesvirus 4, Human; Humans; Lymphocytes; Phosphines; Protein Biosynthesis; RNA; Thymidine
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