Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. VI. Polyoma virus infection.
Int J Cancer, 1979/8;24(2):178-83.
Gresser I, Maury C, Kress C, Blangy D, Maunoury MT
PMID: 226483
Impact factor: 7.316
Abstract
We have determined the effect of a single injection of potent sheep anti-mouse interferon globulin on polyoma-virus-induced early runting disease and tumor formation in Swiss mice. When newborn mice were injected with greater than or equal to 9 X 10(6) PFU of polyoma virus, 16% (7/44) of mice runted and died in contrast to 96% (45/47) of mice injected with virus and anti-interferon globulin. Likewise, a greater percentage of mice injected with lower doses of virus and anti-interferon globulin developed tumors than did control virus-injected mice. These results suggest that interferon is an important factor in determining the susceptibility of newborn mice to polyoma virus.
MeSH terms
Animals; Animals, Newborn; Antibodies, Anti-Idiotypic; Interferons; Mice; Mice, Inbred Strains; Polyomavirus; Tumor Virus Infections
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