Type C virus and immunoglobulin A production by murine myeloma MOPC-315: two independent activities.
Infect Immun, 1979/8;25(2):569-73.
Gazit A, Yaniv A, Halperin D, Ben-Efraim S
PMID: 226480
Impact factor: 3.609
Abstract
The suspected correlation between cessation of type C virus production and halt in immunoglobulin secretion by murine myeloma cells was studied. Employing two variants of the murine myeloma MOPC-315, immunoglobulin A-producing and nonproducing cells, we demonstrated that the two myelomas release similar levels of type C viruses which share common nucleotide sequences and that the viral genomes are equally expressed within the cells. Thus, the suggested relation between these two activities does not apply for MOPC-315 cells and probably for other murine myelomas also.
MeSH terms
Animals; Cell Line; Immunoglobulin A; Mice; Myeloma Proteins; Neoplasms, Experimental; Plasmacytoma; RNA, Viral; Retroviridae; Trinitrobenzenes; Virus Replication
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