Calmodulin activation of adenylate cyclase in pancreatic islets.
Science, 1979/10/12;206(4415):225-7.
Valverde I, Vandermeers A, Anjaneyulu R, Malaisse WJ
PMID: 225798
Impact factor: 63.714
Abstract
Pancreatic islets contain calmodulin. The protein binds to a particulate fraction derived from the islets and stimulates adenylate cyclase activity in this subcellular fraction, both phenomena being activated by ionized calcium. A calcium-dependent stimulation of adenylate cyclase by endogenous calmodulin may contribute to the accumulation of adenosine 3',5'-monophosphate evoked by insulin releasing agents in the islet cells.
MeSH terms
Adenylyl Cyclases; Animals; Calcium; Calcium-Binding Proteins; Calmodulin; Cell Membrane; Cyclic AMP; Egtazic Acid; Enzyme Activation; Female; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Rats
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