Effect of certain inhibitors of glycoprotein synthesis on cell fusion induced by vesicular stomatitis virus.
Microbiol Immunol, 1979;23(3):167-76.
PMID: 225643
Impact factor: 2.962
Abstract
The effect of certain metabolic inhibitors on the fusion of BHK-21 cells induced by vesicular stomatitis virus (VSV) was studied. The polykaryocyte formation in infected cells and virus growth were inhibited by 2-deoxy-D-glucose and D-glucosamine. Host-cell proteins synthesis was suppressed profoundly in both BHK-21-KB and B cells infected with VSV. On the other hand, glycoprotein synthesis was significantly enhanced during the polykaryocyte formation in BHK-21-KB cells, while it was suppressed in BHK-21-B cells which were not sensitive to cell fusion by VSV.
MeSH terms
Animals; Cell Fusion; Cell Line; Cricetinae; Deoxy Sugars; Deoxyglucose; Glucosamine; Glycoproteins; Kidney; Mannose; Protein Biosynthesis; Vesicular stomatitis Indiana virus
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