Large-scale solvent-free chlorination of hydroxy-pyrimidines, -pyridines, -pyrazines and -amides using equimolar POCl₃.
Molecules, 2012/4/16;17(4):4533-44.
Wang H[1], Wen K, Wang L, Xiang Y, Xu X, Shen Y, Sun Z
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PMID: 22508333DOI: 10.3390/molecules17044533
Impact factor: 4.927
Abstract
Chlorination with equimolar POCl₃ can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
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