Effects of D-penicillamine on lymphocyte modulation of synovial collagenase production.
Agents Actions, 1979/6;9(2):172-6.
DeVore DP, Gruebel RJ, Hutson TB, Turner RH
PMID: 224682
Abstract
While D-Penicillamine is effective in the treatment of rheumatoid arthritis, its mechanism of action is unknown. In this study, effects of D-Penicillamine on collagenase production by adherent rheumatoid synovial cells were investigated. D-Penicillamine did not directly affect the synovial collagenase production. However, lymphocyte-free-supernatant (LFS) recovered from lymphocytes exposed to D-Penicillamine in vivo and in vitro significantly reduced collagenase production by adherent synovial cells. LFS from lymphocytes of normal subjects and from non-D-Penicillamine treated rheumatoid patients stimulated collagenase production. These investigations indicate that D-Pencillamine indirectly affects collagenase production by cultured synovial cells and suggests beneficial effects on controlling the primary disease process.
MeSH terms
Arthritis, Rheumatoid; Humans; In Vitro Techniques; Lymphocytes; Microbial Collagenase; Penicillamine; Synovial Membrane
More resources
EndNote: Download