Lymphocyte subpopulation in primary lung cancer.
Oncology, 1979;36(4):176-9.
Alsabti EA, Safo MH, Shaheen A
PMID: 224357
Impact factor: 3.734
Abstract
To determine whether impaired cellular immune responsiveness in lung cancer patients is related to a reduction in the number of T lymphocytes, circulating levels of T-rosette-forming lymphocytes were measured in 48 cases with primary lung cancer and compared to levels in 94 age-matched healthy subjects. The results show that T lymphocytes levels are significantly reduced in lung cancer patients. A possible consequence of reduced numbers of circulating T lymphocytes would be a diminution in tumor-inhibiting (T-cell) influences and a corresponding relative enhancement of blocking (B-cell) influences, a circumstance which would favor tumor proliferation.
MeSH terms
Adenocarcinoma; Adenocarcinoma, Bronchiolo-Alveolar; Aged; B-Lymphocytes; Carcinoma, Squamous Cell; Female; Humans; Immunity, Cellular; Immunoglobulins; In Vitro Techniques; Lung Neoplasms; Male; Middle Aged; Rosette Formation; Skin Tests; T-Lymphocytes
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