ACTH, beta-LPH and beta-endorphin in pituitary adenomas of the patients with Cushing's disease: activation of beta-LPH conversion to beta-endorphin.
J Clin Endocrinol Metab, 1979/9;49(3):475-7.
Suda T, Abe Y, Demura H, Demura R, Shizume K, Tamahashi N, Sasano N
PMID: 224076
Impact factor: 6.134
Abstract
ACTH, beta-lipotropin (beta-LPH) and beta-endorphin concentrations were determined in pituitary adenomas of the patients with Cushing's disease. Immunoreactive ACTH and beta-endorphin were present in high concentrations and essentially equimolar amounts in pituitary adenomas. beta-LPH conversion to beta-endorphin was activated in pituitaries associated with ACTH/beta-LPH producing adenomas. Immunoreactive ACTH and beta-endorphin concentrations were markedly suppressed in the surrounding tissues.
MeSH terms
Adenoma; Adrenocorticotropic Hormone; Cushing Syndrome; Endorphins; Humans; Pituitary Neoplasms; beta-Lipotropin
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