Peripheral beta-receptor responsiveness in patients with essential hypertension.
Arch Intern Med, 1979/8;139(8):879-81.
McAllister RG Jr, Love DW, Guthrie GP Jr, Dominic JA, Kotchen TA
PMID: 223509
Abstract
Peripheral beta-adrenergic receptor sensitivity was characterized in 24 patients with essential hypertension and in 13 age-matched normotensive subjects using an isoproterenol hydrochloride bolus dose-response technique. Decreased beta-receptor responsiveness to this exogenously administered beta-agonist was observed in hypertensive patients; for an equivalent chronotropic effect, higher doses of isoproterenol were required in hypertensive subjects than in normal subjects. Among "normal-renin" hypertensive patients, beta-receptor responsiveness was directly related to furosemide-stimulated plasma renin activity (PRA), suggesting that independently stimulated PRA may provide an indirect estimate of endogenous beta-receptor sensitivity. Hypertensive patients whose mean arterial pressure fell at least 10 mm Hg after four weeks of treatment with hydrochlorothiazide had even further depression in beta-receptor responsiveness, whereas receptor sensitivity was unchanged in patients whose blood pressure was unaffected. Thus, it is unlikely that this decreased receptor responsiveness in patients with untreated essential hypertension is a direct consequence of elevated arterial pressure.
MeSH terms
Adult; Blood Pressure; Dose-Response Relationship, Drug; Female; Furosemide; Humans; Hydrochlorothiazide; Hypertension; Isoproterenol; Male; Middle Aged; Receptors, Adrenergic; Receptors, Adrenergic, beta; Renin
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