Electroconvulsive therapy for iatrogenic hypothalamic-hypopituitarism (CRF-ACTH type).
Am J Psychiatry, 1979/8;136(8):1074-7.
PMID: 223458
Impact factor: 19.242
Abstract
A 41-year-old man with hypothalamic hypopituitarism (CRF-ACTH type) that persisted for 2 years after discontinuation of exogenous dexamethasone was treated with bilateral ECT for severe chronic depression. The depression improved only evanescently after 17 ECT sessions but the hypothalamic-pituitary suppression cleared completely and permanently, based on responses to four metyrapone stress tests in a 2-year follow-up period. ECT may be an effective treatment for persistent hypothalamic-pituitary suppression, even in the absence of a psychiatric disorder.
MeSH terms
Adrenocorticotropic Hormone; Adult; Chronic Disease; Corticotropin-Releasing Hormone; Depression; Dexamethasone; Electroconvulsive Therapy; Humans; Hypopituitarism; Hypothalamo-Hypophyseal System; Iatrogenic Disease; Male; Substance Withdrawal Syndrome
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