Mechanisms of PGF2 alpha action in functional luteolysis.
Adv Exp Med Biol, 1979;112:557-75.
Behrman HR, Luborsky-Moore JL, Pang CY, Wright K, Dorflinger LJ
PMID: 223398
Impact factor: 3.65
Abstract
The luteolytic action of PGF2 alpha appears to be due to loss of gonadotropin support of corpus luteum function. This "chemical hypophysectomy" produced by PGF2 alpha in the rat has several components: 1. A rapid block of gonadotropin uptake in vivo by an unexplained mechanism. 2. A rapid and direct block of adenylate cyclase activation by the LH receptor complex in isolated luteal cells. 3. An eventual loss of LH receptor binding activity produced by inhibition of prolactin action.
MeSH terms
20-alpha-Dihydroprogesterone; Adenylyl Cyclases; Animals; Corpus Luteum; Cyclic AMP; Estrus; Female; Gonadotropins, Pituitary; Luteinizing Hormone; Luteolysis; Pregnancy; Progesterone; Prostaglandins F; Rats; Receptors, Cell Surface; Receptors, Prostaglandin; Regional Blood Flow
More resources
EndNote: Download