Effects of thyrotoxicosis on mitochondrial enzymes of rat soleus.
Horm Metab Res, 1979/4;11(4):304-6.
PMID: 222661
Impact factor: 2.788
Abstract
Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T3 + T4 treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerole-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T3 + T4 treated animals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers.
MeSH terms
Animals; Electron Transport Complex IV; Female; Glycerolphosphate Dehydrogenase; Hyperthyroidism; Mitochondria, Muscle; Rats; Succinate Dehydrogenase; Thyroxine; Triiodothyronine
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