Gastrinoma associated with common bile duct obstruction and the ectopic production of ACTH.
Am J Surg, 1979/6;137(6):800-2.
Kyriakides GK, Silvis SE, Ahmed M, Vennes JA, Vogel SB
PMID: 222162
Impact factor: 3.125
Abstract
A case of adrenocortical hyperfunction due to ectopic production of ACTH by a gastrin-producing tumor of the pancreas is described. Cushing's syndrome preceded the appearance of the overt Zollinger-Ellison syndrome by 2 years and was treated by bilateral adrenalectomy. The Zollinger-Ellison syndrome was initially treated with cimetidine, which successfully reduced the secretion of gastric acid. Because the pancreatic gastrinoma continued to grow, causing obstruction of the common bile duct, biliary diversion and total gastrectomy were performed. There is evidence that the pancreatic gastrinoma was the source of the ectopic production of ACTH and possibly secretion. The role of Histamine-2 blocking agents as therapy in the Zollinger-Ellison syndrome is discussed.
MeSH terms
Adrenocorticotropic Hormone; Adult; Biliary Tract Diseases; Cholestasis; Common Bile Duct; Constriction, Pathologic; Gastrins; Hormones, Ectopic; Humans; Male; Pancreatic Neoplasms
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