The stability constants of some metal ion complexes of 3',5'-cyclic AMP.
J Cyclic Nucleotide Res, 1979;5(2):145-51.
PMID: 221553
Abstract
The stability constants of complexes of 3', 5'-cyclic AMP with Mg2+, Ca2+, Mn2+, Ni2+ and Co2+ were estimated at 30 degrees C in solutions of ionic strength about 0.15 containing about 130 mM K+ or tetramethylammonium ions. Values between 13 and 22 M-1 were obtained, indicating that only about 2% of cyclic AMP is present as metal complexes in vivo, but that at commonly used in vitro concentrations of 10 mM bivalent metal ions, 10--20% of cyclic AMP is present as metal complexes. The possible significance of these metal complexes, for example as competitive inhibitors, is discussed.
MeSH terms
Calcium; Cations, Divalent; Cobalt; Cyclic AMP; Drug Stability; Ion Exchange Resins; Magnesium; Manganese; Nickel; Osmolar Concentration
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