Lymphocyte transformation and interferon production as measures of cellular immunity in lymphoma patients.
IARC Sci Publ, 1978;(24 Pt 2):745-51.
Arvin AM, Pollard RB, Rasmussen LE, Rand KH, Merigan TC
PMID: 221398
Abstract
Our studies of in vitro cellular immune responses to herpesviruses have shown that, before treatment, lymphoma patients have decreased transformation to varicella-zoster virus antigen compared to herpes simplex virus and cytomegalovirus antigens. Interferon production to varicella-zoster virus and cytomegalovirus antigens is also decreased. During the first six months of treatment, decreased lymphocyte transformation and interferon production to all herpesviral antigens was observed. Among patients in long-term remission, recovery from the suppression associated with treatment was noted except that interferon production to varicella-zoster virus antigen remained decreased.
MeSH terms
Antigens, Viral; Cytomegalovirus; Herpesvirus 3, Human; Humans; Immunity, Cellular; Immunosuppression Therapy; In Vitro Techniques; Interferons; Lymphocyte Activation; Lymphoma; Simplexvirus; Time Factors
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