Non-protective variants of Marek's disease vaccine viruses.
IARC Sci Publ, 1978;(24 Pt 2):1043-7.
PMID: 221372
Abstract
Two variant Marek's disease-vaccine viruses failed to induce protective immune responses in chickens and replicated poorly in vivo. One of these, MDV/200D, was defective for growth at 41 degrees C, and clones from this stock had 38 degrees C/41 degrees C plating ratios as high as 10(4). The basis for the poor in vivo replicative ability was not determined.
MeSH terms
Animals; Chickens; Defective Viruses; Herpesviridae; Herpesvirus 2, Gallid; Marek Disease; Temperature; Turkeys; Viral Vaccines
More resources
EndNote: Download