Effect of cyclic nucleotides on the response of cells to infection by various herpesviruses.
IARC Sci Publ, 1978;(24 Pt 1):381-7.
PMID: 221343
Abstract
The effect of varying the intracellular cyclic nucleotide concentration of mouse cells infected with HSV-1 or of duck embryo fibroblasts infected with Marek's disease virus has been studied. It has been shown in each case that agents that elevate the intracellular cAMP levels increase the yield of infectious virus or viral DNA, but inhibit cell division. cGMP enhances synthesis of viral DNA but allows continued synthesis of cell DNA.
MeSH terms
Animals; Cell Transformation, Viral; Cells, Cultured; Cyclic AMP; Cyclic GMP; DNA; DNA, Viral; Herpesviridae; Prostaglandins E, Synthetic; Virus Replication
More resources
EndNote: Download