Antiviral action of benzo[de]isoquinoline-1,3-diones: 5-nitro-2-(2-dimethylaminoethyl) and 5-nitro-2-[2-(1-pyrrolidine)-ethyl] derivatives.
Chemotherapy, 1979;25(2):83-90.
García-Gancedo A, Gil C, Roldán CM, Pérez S, Vilas P
PMID: 221156
Impact factor: 3.549
Abstract
Two benzo[de]isoquinoline-diones, namely 5-nitro-2-(2-dimethylaminoethyl)-benzo[de]isoquinoline-1,3-dione and 5-nitro-2-[2-(1-pyrrolidine)-ethyl]-benzo[de]isoquinoline-1,3-dione, caused inhibition of the viral replication, when assayed against herpes simplex and vaccinia viruses in chick embryo cell cultures. Influenza and Sindbis virus replication were unaffected by these chemicals. Virucidal effects were unobserved. The inhibitory activity is time-related. Ocular and dermal infections with vaccinia virus in rabbits were prevented or disease severity reduced whenever they were treated with either one of these two drugs.
MeSH terms
Animals; Antiviral Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Chick Embryo; Drug Evaluation, Preclinical; Eye Diseases; Influenza A virus; Isoquinolines; Rabbits; Simplexvirus; Sindbis Virus; Skin Diseases, Infectious; Time Factors; Vaccinia; Vaccinia virus; Virus Replication
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