Electron microscopic studies on transplantable mucus-secreting and tubular adenocarcinomas of colo-rectal origin in ACI/N rats.
Tohoku J Exp Med, 1979/3;127(3):289-99.
PMID: 220752
Impact factor: 2.547
Abstract
Two transplantable, one mucus-producing (R-1) and the other tubular but less mucinous (R-2), adenocarcinomas were investigated electron microscopically. The R-1 tumor was composed of a large number of intermediate cells and mucus-producing cells, incompletely differentiated goblet-like cells and absorptive-like cells, and a small number of undifferentiated cells. The electron microscopic features of the mucus-producing cells exhibited distinctive features different from those of the epithelium of normal colon. They had highly electron-dense granules, expanded rER, well-developed mitochondria and Golgi apparatus. The R-1 tumor was found to be a well-differentiated adenocarcinoma in agreement with observations by light microscopy, while the R-2 tumor exhibited more malignant features than R-1.
MeSH terms
Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Colonic Neoplasms; Microscopy, Electron; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred ACI; Rectal Neoplasms
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