Renal hyperconcentration of 99mTc-HEDP in experimental acute tubular necrosis.
Radiology, 1979/5;131(2):491-5.
Lavelle KJ, Park HM, Moseman AM, Lewis S
PMID: 220670
Impact factor: 29.146
Abstract
The effect of transient renal ischemia on renal concentration and distribution of 99mTc-HEDP, 99mTc-DMSA, and 99mTc-DTPA was compared in rabbits with acute tubular necrosis. Scintigrams were obtained after injection in normal rabbits or ones with unilateral or bilateral ischemia. 99mTc-HEDP concentration in ischemic tissue was 8 to 18 times normal 1--4 hours after injection, and the resulting images delineated the morphological changes in the ischemic kidneys more accurately than those obtained with DMSA or DTPA. Calcium concentration in the ischemic kidneys increased sixfold. 99mTc-HEDP may be useful in evaluation of renal failure secondary to tubular injury.
MeSH terms
Acute Kidney Injury; Animals; Calcium; Etidronic Acid; Female; Ischemia; Kidney; Kidney Tubular Necrosis, Acute; Male; Rabbits; Radionuclide Imaging; Succimer; Technetium
More resources
EndNote: Download