Tardive dyskinesia: a clinical test of the supersensitivity hypothesis.
Psychopharmacology (Berl), 1979/3/22;61(2):137-41.
Bowers MB Jr, Moore D, Tarsy D
PMID: 220654
Impact factor: 4.415
Abstract
Patients with tardive dyskinesia showed no significant difference in CSF HVA when compared with groups of schizophrenic or depressives. CSF cAMP in the tardive dyskinesia group was significantly lower when compared to schizophrenics but not depressives. These results do not support a dopamine-receptor supersensitivity hypothesis in permanent tardive dyskinesia.
MeSH terms
Adult; Aged; Clinical Trials as Topic; Cyclic AMP; Depression; Dyskinesia, Drug-Induced; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Probenecid; Receptors, Dopamine; Schizophrenia
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