Long-term effect of ovariectomy on dopamine-stimulated adenylate cyclase in rat striatum and nucleus accumbens.
Psychopharmacology (Berl), 1979/3/14;61(1):13-6.
Kumakura K, Hoffman M, Cocchi D, Trabucchi M, Spano PF, Müller EE
PMID: 220653
Impact factor: 4.415
Abstract
The long-term effects on dopamine-sensitive adenylate cyclase of deprivation of gonadal steroids resulting from ovariectomy were studied in extrahypothalamic areas of the brain, i.e. corpus striatum and nucleus accumbens. The results obtained show that in both central nervous system areas dopamine- and apomorphine-stimulated adenylate cyclase were significantly reduced, suggesting that the function of dopamine receptors in these areas was depressed.
MeSH terms
Adenylyl Cyclases; Animals; Apomorphine; Castration; Corpus Striatum; Cyclic AMP; Dopamine; Female; Hypophysectomy; Nucleus Accumbens; Rats; Septal Nuclei; Time Factors
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