Monovalent cation transport in myotonic dystrophy. Na-K pump ratio in erythrocytes.
J Neurol Sci, 1979/5;41(3):299-306.
Hobbs AS, Brumback RA, Festoff BW
PMID: 220392
Impact factor: 4.553
Abstract
Myotonic dystrophy is a dominantly-inherited disorder which affects skeletal muscle in combination with several other systems. Because of abnormalities in red blood cells, a universal membrane defect has been proposed as the primary disturbance. Erythrocyte cation pump ratios have also been reported to be abnormal. Hyperinsulinemia and glucose intolerance are present in a large number of patients. Since dramatic effects of insulin on membrane cation transport have been shown in several tissues, notably skeletal muscle, we wished first to confirm reports of altered pump ratio in these patients and then to evaluate the effects of insulin on cation fluxes. However, in our experiments myotonic dystrophy patients had normal pump ratios when compared with disease controls.
MeSH terms
Carrier Proteins; Cell Membrane Permeability; Erythrocyte Membrane; Erythrocytes; Humans; Insulin; Myotonic Dystrophy; Phenytoin; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase
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