Antiestrogen inhibits the induction of progestin receptors by estradiol in the hypothalamus-preoptic area and pituitary.
Endocrinology, 1979/5;104(5):1333-6.
Roy EJ, MacLusky NJ, McEwen BS
PMID: 220031
Impact factor: 5.051
Abstract
Estradiol treatment of ovariectomized-adrenalectomized rats produced an increase in cytosol progestin binding in the hypothalamus-preoptic area (HPOA), pituitary, and uterus. In the HPOA and pituitary, this induction of progestin receptors by estradiol was inhibited by the antiestrogen CI-628 under a variety of dose and time conditions. In the uterus, inhibition of the full effect of estradiol on progestin binding was observed after 3 days of injection of antiestrogen and estradiol. In the absence of estradiol, the antiestrogen produced a slight induction of progestin receptors in the HPOA and pituitary and a substantial induction of progestin receptors in the uterus. The results suggest that the induction of progestin receptors could be a key intermediate step in some behavioral and neuroendocrine actions of estradiol.
MeSH terms
Animals; Estradiol; Estrogen Antagonists; Female; Hypothalamus; Nitromifene; Pituitary Gland; Preoptic Area; Progestins; Pyrrolidines; Rats; Receptors, Cell Surface; Uterus
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