A case of pituitary adrenocorticotropin-dependent Cushing's syndrome in the horse.
Endocrinology, 1979/3;104(3):576-82.
Moore JN, Steiss J, Nicholson WE, Orth DN
PMID: 220013
Impact factor: 5.051
Abstract
In the horse, a syndrome of hirsutism, hyperglycemia, glucosuria, polydipsia, polyuria, polyphagia, and progressive debilitation has been recognized. Most often the syndrome has been associated with adenomas of the pars intermedia of the pituitary and bilateral adrenal hyperplasia or nodular hyperplasia involving primarily the zona fasciculata. Previously, the syndrome has been ascribed to compression of the hypothalamus by an expanding but functionally inactive pituitary neoplasm. In the present case, with RIA determination of plasma ACTH concentrations, the syndrome was ascribed to pituitary ACTH-dependent hyperadrenocorticism and likened to human Cushing's disease.
MeSH terms
Adrenocorticotropic Hormone; Animals; Brain; Cushing Syndrome; Female; Glucose Tolerance Test; Horse Diseases; Horses; Hydrocortisone; Pituitary Gland; Pituitary Neoplasms
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