The absence of a role for the carbohydrate moiety in the binding of apolipoprotein B to the low density lipoprotein receptor.
Biochim Biophys Acta, 1979/3/29;572(3):537-40.
PMID: 219898
Abstract
The binding of low density lipoprotein (LDL) to fibroblasts occurs through apolipoprotein B, a glycoprotein. The role of the carbohydrate in binding was assessed in two ways: (1) LDL, freed of sialic acid and most of the glucosamine and hexoses by digestion with a mixture of glycosidases, bound to fibroblasts as does native LDL. (2) The glycopeptides liberated from apoprotein B by trypsin and pronase failed to inhibit LDL binding to fibroblasts. Apparently the carbohydrate moiety of LDL does not interact with the plasma membrane receptor.
MeSH terms
Apolipoproteins; Carbohydrates; Fibroblasts; Glucosamine; Glycoside Hydrolases; Hexoses; Lipoproteins, LDL; Receptors, Drug; Sialic Acids
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