Cell-mediated cytotoxicity against hamster cells transformed by avian sarcoma viruses. 2. Sensitivity of different subclones.
Ann Rech Vet, 1978;9(3):551-8.
PMID: 219754
Abstract
The presence of new antigens on different subclones of hamster cells transformed by avian sarcoma viruses was investigated by an in vitro cellular microcytotoxicity assay. The RS 2/3 and RS 2/10 subclones derived from the RS 2 clone, transformed with a Schmidt-Ruppin strain of RSV were highly sensitive to the cytotoxic action of spleen effector cells obtainled from hamsters immunized with RSV-transformed rat cells. The RS 2/6 subclone was sensitive only when 1,000 target cells were seeded and the RS 2/7 subclone was not susceptible to the cytotoxic action of effector cells. The RB 12/1 subclone, derived from the clone RB 12, transformed with a Bryan strain of RSV was poorly sensitive. The comparison between the sensitivity to XC-sensitized spleen cells of the different subclones and their other known properties was discussed.
MeSH terms
Animals; Antigens, Neoplasm; Avian Sarcoma Viruses; Cell Line; Clone Cells; Cricetinae; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Immunity, Cellular; Mesocricetus; Rats; Sarcoma, Avian; Spleen
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