Prolongation of islet allograft survival.
Transplantation, 1979/3;27(3):171-4.
Lacy PE, Davie JM, Finke EH, Scharp DW
PMID: 219566
Impact factor: 5.385
Abstract
Pretreatment of donor rats with irradiation and silica followed by in vitro culture of the islets for 1 to 2 days prolonged survival of allografts across a minor histocompatibility barrier if "hand-picked," clean islets were used for transplantation. Pretreatment of donor rats with irradiation and silica in conjunction with a single injection of antilymphocyte serum (ALS) into the recipient produced a prolongation of survival of hand-picked islets transplanted across a major histocompatibility barrier.
MeSH terms
Animals; Antilymphocyte Serum; Cells, Cultured; Diabetes Mellitus, Experimental; Female; Graft Survival; In Vitro Techniques; Islets of Langerhans Transplantation; Male; Preoperative Care; Radiotherapy Dosage; Rats; Silicon Dioxide; Streptozocin; Time Factors; Transplantation, Homologous
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