[Effect of the lipid-lowering agent, procetofen, on the makeup of human biliary lipids].
Schweiz Med Wochenschr, 1979/4/21;109(16):601-2.
Grandjean EM, Mordasini R, Paumgartner G
PMID: 219470
Abstract
The effect of lipid-lowering treatment with procetofen (3 x 100 mg/day for 4-6 weeks) on the cholesterol saturation index (S.I.) of bile has been studied in 6 patients with type IIa or IIb pattern hyperlipoproteinemia. Compared with a control period with placebo, the S.I. was increased by more than 20% during active treatment in 2 patients. Oversaturation was reached in one case. In the other 4 patients, the changes did not exceed 20% of the control value. Thus, increased lithogenicity of bile does not appear to be a frequent effect of procetofen. A larger number of patients should therefore be studied to establish its true incidence.
MeSH terms
Adult; Bile; Cholesterol; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Hypolipidemic Agents; Lipids; Lipoproteins, LDL; Lipoproteins, VLDL; Male; Middle Aged; Propionates; Time Factors
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