25-Azavitamin D3, an inhibitor of vitamin D metabolism and action.
J Biol Chem, 1979/5/10;254(9):3493-6.
Onisko BL, Schnoes HK, DeLuca HF
PMID: 218970
Abstract
25-Azavitamin D3 inhibited both the bone calcium mobilization and intestinal calcium transport responses of rats to vitamin D3 but not to 25-hydroxyvitamin D3. Although 25-azavitamin D3 had no effect on the response of bone to 1alpha,25-dihydroxyvitamin D3, it did diminish the response of the intestine to that metabolite. 25-Azavitamin D3 increased liver vitamin D content and reduced the concentration of 25-hydroxyvitamin D3 required to inhibit the metabolism of vitamin D3 (75 and 200 microgram) were similar to the doses of 25-azavitamin D3 required to inhibit the action of vitamin D3 in vivo (50 and 150 microgram). 25-Azavitamin D3 is thus a vitamin D antagonist, acting for the most part via inhibition of the liver 25-hydroxylation of vitamin D3.
MeSH terms
Animals; Biological Assay; Bone and Bones; Calcium; Cholecalciferol; Dihydroxycholecalciferols; Duodenum; Hydroxycholecalciferols; Intestinal Absorption; Liver; Male; Rats; Vitamin D
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