[Effects of fasting and of ACTH on renal compensatory hypertrophy in the 48 hour uninephrectomized rat].
C R Seances Soc Biol Fil, 1978;172(4):713-7.
Reville P, de Laharpe F, Compagnie MJ, Stephan F
PMID: 218701
Abstract
Renal compensatory hypertrophy (R.C.H.) is determined 48 h. after uninephrectomy in fed and fasting rats having free access to a NaCl solution. ACTH (18 gamma/100 g BW/d/2d) enhances R.C.H. in the fed animals. R.C.H. is severely impaired by food deprivation and the remaining kidney looses weight; a normal kidney weight can be maintained if the fasted, uninephrectomized rat is treated with ACTH. These experiments suggest that the stimulation of the adrenal cortex by ACTH has a renotrophic effect. This action may be related to the elevation of blood glucose or/and to the fall of the concentration of plasma K+.
MeSH terms
Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Fasting; Female; Hypertrophy; Kidney; Nephrectomy; Rats
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