[Response to ACTH of human adrenocortical cells isolated from normal glands and from adrenocortical adenoma (author's transl)].
Ann Endocrinol (Paris), 1978;39(6):485-6.
Kolanowski J, Ortega N, Crabbé J
PMID: 218494
Impact factor: 3.117
Abstract
The low sensitivity of adrenocortical adenoma to ACTH, documented in vivo, and in vitro, results from decreased cAMP generation in response to ACTH while distal steps of biosynthesis of cortisol are even more active in these tumoral cells than in normal adrenocortical cells.
MeSH terms
Adenoma; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Cyclic AMP; Humans; Hydrocortisone
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