Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.
Proc Natl Acad Sci U S A, 1979/1;76(1):442-6.
Finberg R, Weiner HL, Fields BN, Benacerraf B, Burakoff SJ
PMID: 218202
Impact factor: 12.779
Abstract
Cytotoxic T lymphocytes (CTLs) can be generated if spleen cells from reovirus-infected mice are stimulated in vitro with syngeneic reovirus-infected cells. These cytolytic effector cells demonstrate: (i) serotype specificity (i.e., maximal cytolytic activity is observed on target cells infected with the serotype used to induce the CTLs) and (ii) H-2 restriction. The SI gene was shown to be the predominant viral gene determining the specificity of the cytotoxic T cells. This genome segment has previously been demonstrated to encode the viral hemagglutinin and determines reovirus cell tropism in the nervous system.
MeSH terms
Animals; Cytotoxicity, Immunologic; Genes, MHC Class II; Genes, Viral; H-2 Antigens; Major Histocompatibility Complex; Mice; Reoviridae; Reoviridae Infections; T-Lymphocytes
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