[Substances having antiviral activity. IX. Synthesis and antiviral activity of 1-acyl-2-halo-3-formylindole thiosemicarbazones].
Farmaco Sci, 1978/10;33(10):754-60.
Andreani A, Bonazzi D, Cavrini V, Gatti R, Giovanninetti G, Rambaldi M, Franchi L, Nanetti A, Guarda MA
PMID: 217729
Abstract
Some thiosemicarbazones of 1-acyl-2-chloro-3-formylindoles were synthesized and investigated for antiviral activity against vaccinia virus, HID stock and parainfluenza virus type 3 HA-I/CR-8 stock. Evidence of antiviral activity was found only against vaccinia virus, and was particular significant with the m-substituted 1-benzoyl-2-chloro-3-formylindoles. The first results of 2-substitution of chlorine by bromine in the indole skeleton, are reported.
MeSH terms
Antiviral Agents; Indoles; Parainfluenza Virus 3, Human; Structure-Activity Relationship; Thiosemicarbazones; Vaccinia virus
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