Acetaldehyde affects mammalian neuromuscular transmission without observable postsynaptic effects.
Can J Physiol Pharmacol, 1978/12;56(6):1063-6.
Carlen PL, Staiman AL, Corrigall WA
PMID: 217509
Impact factor: 2.245
Abstract
Acetaldehyde, the first metabolite of ethanol, caused a reversible block of the end-plate potential (EPP) in the rat and mouse phrenic nerve--hemidiaphragm preparation. Decrease and block of the EPP occurred over a bath concentration range from 3 to 25 mM. The phrenic nerve compound action potential was blocked along with the EPP, and this block was not reversed by high bath Ca2+ concentration. The muscle action potential was unaffected even at concentrations up to 50 mM. Over the same concentration range (3--25 mM), miniature end-plate potential (MEPP) frequency sometimes decreased a few minutes after application, and over the ensuing 10--20 min would steadily increase to as much as 11 times the base-line frequency, particularly with higher doses. However, the shape of averaged MEPPs remained unchanged after acetaldehyde application, suggesting that this aldehyde does not have post-synaptic effects.
MeSH terms
Acetaldehyde; Action Potentials; Animals; In Vitro Techniques; Male; Membrane Potentials; Mice; Motor Endplate; Neuromuscular Junction; Rats; Synapses; Synaptic Transmission; Time Factors
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