Enhancement of alcohol withdrawal seizures with 6-hydroxydopamine.
Epilepsia, 1978/12;19(6):603-9.
PMID: 216544
Impact factor: 6.74
Abstract
The relationship between central catecholamine neurons and alcohol withdrawal seizures was studied in rats pretreated with 6-hydroxydopamine to selectively destroy the central catecholamine nerve terminals. The alteration of alcohol withdrawal seizures was manifested by (1) a higher percentage of the rats developing the seizures, (2) an earlier onset of seizures, and (3) a greater severity of seizure activity. Seizure status was exhibited in 25% of the 6-hydroxydopamine-treated rats.
MeSH terms
Acoustic Stimulation; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Humans; Hydroxydopamines; Premedication; Rats; Receptors, Neurotransmitter; Seizures; Substance Withdrawal Syndrome
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