Alterations of adrenal and uterine angiotensin II receptors during variation of sodium intake and/or experimental hypertension.
Clin Sci Mol Med Suppl, 1978/12;4:171S-174S.
Devynck MA, Pernollet MG, Macdonald GJ, Matthews PG, Raisman RS, Meyer P
PMID: 215372
Abstract
1. Angiotensin II receptors from rat adrenal gland and myometrium were studied during variation of sodium intake. 2. In both target-tissues low Na+ diet increased the number of receptors whereas a high Na+ diet did not modify the adrenocortical receptors but increased the number of uterine receptors. 3. Deoxycorticosterone and one kidney Goldblatt hypertension were associated with a decrease in the number of adrenal receptors. 4. Alterations of angiotensin II receptors alone cannot explain satisfactorily the variations of sensitivity of target-cells to angiotensin II during sodium balance changes.
MeSH terms
Adrenal Glands; Angiotensin II; Animals; Desoxycorticosterone; Female; Hypertension; Myometrium; Rats; Receptors, Angiotensin; Receptors, Cell Surface; Renin; Sodium Chloride; Uterus
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