Experiences with thymosin in primary immunodeficiency disease.
Cancer Treat Rep, 1978/11;62(11):1779-85.
Astaldi A, Astaldi GC, Wijermans P, Dagna-Bricarelli F, Kater L, Stoop JW, Vossen JM
PMID: 215306
Abstract
Thymosin has no effect in vitro on cyclic AMP levels in thymocytes. However, when thymosin was injected into patients lacking "serum factor" (SF) activity, it induced the appearance of SF or SF-like activity and the disappearance of target cells for SF among the peripheral blood lymphocytes of the treated patients. On the other hand, when thymosin was injected into one patient with normal SF activity, it induced a marked decrease of SF activity and the appearance of target cells for SF among the peripheral blood lymphocytes of this particular patient.
MeSH terms
Animals; Child; Child, Preschool; Cyclic AMP; Female; Humans; Immunologic Deficiency Syndromes; In Vitro Techniques; Infant; Infant, Newborn; Male; Mice; T-Lymphocytes; Thymosin; Thymus Hormones
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