Preliminary results of combined surgery and adjuvant Bacillus Calmette-Guérin plus levamisole treatment of resectable lung cancer.
Cancer Treat Rep, 1978/11;62(11):1671-5.
Wright PW, Hill LD, Peterson AV Jr, Pinkham R, Johnson L, Ivey T, Bernstein I, Bagley C, Anderson R
PMID: 215304
Abstract
The administration of intrapleural bacillus Calmette-Guérin (BCG) alone and intrapleural BCG plus levamisole was compared to placebo in patients with resectable, non-small cell cancer of the lung. This report is based on an interim analysis of 100 eligible patients with a median followup of 245 days. No significant treatment effects are apparent at the present time, although current trends are consistent with an approximate 30% reduction in recurrence rate in patients receiving intrapleural BCG. There is little evidence to suggest that the addition of levamisole will contribute to this effect. A relationship between purified protein derivative conversion and tumor recurrence is apparent. Failure to manifest purified protein derivative conversion following administration of intrapleural BCG is associated with a significantly greater risk of tumor recurrence.
MeSH terms
Adenocarcinoma; Aged; BCG Vaccine; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Clinical Trials as Topic; Female; Humans; Immunity; Levamisole; Lung Neoplasms; Male; Middle Aged; Recurrence; Tuberculin Test
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