Potentiation of isoprenaline-induced plasma cyclic AMP response by aminophylline in normal and asthmatic subjects.
Br J Clin Pharmacol, 1978/12;6(6):499-503.
PMID: 215179
Impact factor: 3.716
Abstract
1 The effect of intravenous aminophylline infusion (6 mg-1 kg in 20 min, then 0.9 mg-1 kg-1 h thereafter) and its interaction with inhaled isoprenaline (800 microgram ex inhaler) on plasma cyclic AMP levels was studied in five normal and five asthmatic subjects. 2 Aminophylline infusion alone did not significantly change plasma cyclic AMP levels in either group. 3 In both groups, the plasma cyclic AMP response to isoprenaline aerosol inhalation was enhanced by aminophylline, although to a lesser degree in the asthmatic subjects. 4 The results provide in vivo evidence consistent with the hypothesis that in man, therapeutic doses of aminophylline may exert their clinical effects by inhibition of cyclic AMP phosphodiesterase.
MeSH terms
Adult; Aminophylline; Asthma; Cyclic AMP; Drug Synergism; Edetic Acid; Humans; Isoproterenol; Middle Aged; Time Factors
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