Parainfluenza-3 virus: difference in capacity of neuraminidase-weak and strong strains to infect young calves and to elicit cellular immune response.
Res Vet Sci, 1978/9;25(2):193-9.
PMID: 214834
Impact factor: 2.554
Abstract
Calves less than four weeks old could not be infected with a neuraminidase-weak strain of parainfluenza-3 virus (Pi3) but were successfully infected with either of two neuraminidase-strong strains. The criteria for infection were virus excretion, cell-mediated and antibody-mediated immune responses. In the lymphocyte stimulation test, calves infected with the neuraminidase-strong Pi3 strain Tüb-E6 responded more strongly to antigen prepared from this strain than to antigen from the heterologous Pi3 strain Um-23. The non-immunoglobulin haemagglutination inhibition activity of the liquid phase of nasal secretions of newborn calves decreased after treatment with Vibrio cholerae neuraminidase. For virus-bound neuraminidase the liquid phase from newborn calves was a richer substrate than the liquid phase from older animals.
MeSH terms
Animals; Animals, Newborn; Antigens, Viral; Cattle; Cattle Diseases; Hemagglutination Inhibition Tests; Immunity, Cellular; Lymphocytes; Neuraminidase; Parainfluenza Virus 3, Human; Paramyxoviridae Infections; Respirovirus
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